Identification of a severe acute respiratory syndrome coronavirus-like virus in a leaf-nosed bat in Nigeria.
Identifieur interne : 002527 ( Main/Exploration ); précédent : 002526; suivant : 002528Identification of a severe acute respiratory syndrome coronavirus-like virus in a leaf-nosed bat in Nigeria.
Auteurs : Phenix-Lan Quan [États-Unis] ; Cadhla Firth ; Craig Street ; Jose A. Henriquez ; Alexandra Petrosov ; Alla Tashmukhamedova ; Stephen K. Hutchison ; Michael Egholm ; Modupe O V. Osinubi ; Michael Niezgoda ; Albert B. Ogunkoya ; Thomas Briese ; Charles E. Rupprecht ; W Ian LipkinSource :
- mBio [ 2150-7511 ] ; 2010.
Descripteurs français
- KwdFr :
- Animaux, Chiroptera (virologie), Données de séquences moléculaires, Humains, Nigeria, Phylogénie, Réservoirs d'agents pathogènes (virologie), Syndrome respiratoire aigu sévère (transmission), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (isolement et purification).
- MESH :
- génétique : Virus du SRAS.
- isolement et purification : Virus du SRAS.
- virologie : Chiroptera, Réservoirs d'agents pathogènes, Syndrome respiratoire aigu sévère.
- Animaux, Données de séquences moléculaires, Humains, Nigeria, Phylogénie, Syndrome respiratoire aigu sévère, Virus du SRAS.
- Wicri :
- geographic : Nigeria.
English descriptors
- KwdEn :
- Animals, Chiroptera (virology), Disease Reservoirs (virology), Humans, Molecular Sequence Data, Nigeria, Phylogeny, SARS Virus (classification), SARS Virus (genetics), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (transmission), Severe Acute Respiratory Syndrome (virology).
- MESH :
- geographic : Nigeria.
- classification : SARS Virus.
- genetics : SARS Virus.
- isolation & purification : SARS Virus.
- transmission : Severe Acute Respiratory Syndrome.
- virology : Chiroptera, Disease Reservoirs, Severe Acute Respiratory Syndrome.
- Animals, Humans, Molecular Sequence Data, Phylogeny.
Abstract
Bats are reservoirs for emerging zoonotic viruses that can have a profound impact on human and animal health, including lyssaviruses, filoviruses, paramyxoviruses, and severe acute respiratory syndrome coronaviruses (SARS-CoVs). In the course of a project focused on pathogen discovery in contexts where human-bat contact might facilitate more efficient interspecies transmission of viruses, we surveyed gastrointestinal tissue obtained from bats collected in caves in Nigeria that are frequented by humans. Coronavirus consensus PCR and unbiased high-throughput pyrosequencing revealed the presence of coronavirus sequences related to those of SARS-CoV in a Commerson's leaf-nosed bat (Hipposideros commersoni). Additional genomic sequencing indicated that this virus, unlike subgroup 2b CoVs, which includes SARS-CoV, is unique, comprising three overlapping open reading frames between the M and N genes and two conserved stem-loop II motifs. Phylogenetic analyses in conjunction with these features suggest that this virus represents a new subgroup within group 2 CoVs.
DOI: 10.1128/mBio.00208-10
PubMed: 21063474
Affiliations:
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Henriquez</name></author><author><name sortKey="Petrosov, Alexandra" sort="Petrosov, Alexandra" uniqKey="Petrosov A" first="Alexandra" last="Petrosov">Alexandra Petrosov</name></author><author><name sortKey="Tashmukhamedova, Alla" sort="Tashmukhamedova, Alla" uniqKey="Tashmukhamedova A" first="Alla" last="Tashmukhamedova">Alla Tashmukhamedova</name></author><author><name sortKey="Hutchison, Stephen K" sort="Hutchison, Stephen K" uniqKey="Hutchison S" first="Stephen K" last="Hutchison">Stephen K. Hutchison</name></author><author><name sortKey="Egholm, Michael" sort="Egholm, Michael" uniqKey="Egholm M" first="Michael" last="Egholm">Michael Egholm</name></author><author><name sortKey="Osinubi, Modupe O V" sort="Osinubi, Modupe O V" uniqKey="Osinubi M" first="Modupe O V" last="Osinubi">Modupe O V. 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Rupprecht</name></author><author><name sortKey="Lipkin, W Ian" sort="Lipkin, W Ian" uniqKey="Lipkin W" first="W Ian" last="Lipkin">W Ian Lipkin</name></author></analytic><series><title level="j">mBio</title><idno type="eISSN">2150-7511</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chiroptera (virology)</term><term>Disease Reservoirs (virology)</term><term>Humans</term><term>Molecular Sequence Data</term><term>Nigeria</term><term>Phylogeny</term><term>SARS Virus (classification)</term><term>SARS Virus (genetics)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (transmission)</term><term>Severe Acute Respiratory Syndrome (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chiroptera (virologie)</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Nigeria</term><term>Phylogénie</term><term>Réservoirs d'agents pathogènes (virologie)</term><term>Syndrome respiratoire aigu sévère (transmission)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS ()</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (isolement et purification)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Nigeria</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term><term>Réservoirs d'agents pathogènes</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term><term>Disease Reservoirs</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Molecular Sequence Data</term><term>Phylogeny</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Nigeria</term><term>Phylogénie</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Nigeria</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bats are reservoirs for emerging zoonotic viruses that can have a profound impact on human and animal health, including lyssaviruses, filoviruses, paramyxoviruses, and severe acute respiratory syndrome coronaviruses (SARS-CoVs). In the course of a project focused on pathogen discovery in contexts where human-bat contact might facilitate more efficient interspecies transmission of viruses, we surveyed gastrointestinal tissue obtained from bats collected in caves in Nigeria that are frequented by humans. Coronavirus consensus PCR and unbiased high-throughput pyrosequencing revealed the presence of coronavirus sequences related to those of SARS-CoV in a Commerson's leaf-nosed bat (Hipposideros commersoni). Additional genomic sequencing indicated that this virus, unlike subgroup 2b CoVs, which includes SARS-CoV, is unique, comprising three overlapping open reading frames between the M and N genes and two conserved stem-loop II motifs. Phylogenetic analyses in conjunction with these features suggest that this virus represents a new subgroup within group 2 CoVs.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><noCountry><name sortKey="Briese, Thomas" sort="Briese, Thomas" uniqKey="Briese T" first="Thomas" last="Briese">Thomas Briese</name><name sortKey="Egholm, Michael" sort="Egholm, Michael" uniqKey="Egholm M" first="Michael" last="Egholm">Michael Egholm</name><name sortKey="Firth, Cadhla" sort="Firth, Cadhla" uniqKey="Firth C" first="Cadhla" last="Firth">Cadhla Firth</name><name sortKey="Henriquez, Jose A" sort="Henriquez, Jose A" uniqKey="Henriquez J" first="Jose A" last="Henriquez">Jose A. Henriquez</name><name sortKey="Hutchison, Stephen K" sort="Hutchison, Stephen K" uniqKey="Hutchison S" first="Stephen K" last="Hutchison">Stephen K. Hutchison</name><name sortKey="Lipkin, W Ian" sort="Lipkin, W Ian" uniqKey="Lipkin W" first="W Ian" last="Lipkin">W Ian Lipkin</name><name sortKey="Niezgoda, Michael" sort="Niezgoda, Michael" uniqKey="Niezgoda M" first="Michael" last="Niezgoda">Michael Niezgoda</name><name sortKey="Ogunkoya, Albert B" sort="Ogunkoya, Albert B" uniqKey="Ogunkoya A" first="Albert B" last="Ogunkoya">Albert B. Ogunkoya</name><name sortKey="Osinubi, Modupe O V" sort="Osinubi, Modupe O V" uniqKey="Osinubi M" first="Modupe O V" last="Osinubi">Modupe O V. Osinubi</name><name sortKey="Petrosov, Alexandra" sort="Petrosov, Alexandra" uniqKey="Petrosov A" first="Alexandra" last="Petrosov">Alexandra Petrosov</name><name sortKey="Rupprecht, Charles E" sort="Rupprecht, Charles E" uniqKey="Rupprecht C" first="Charles E" last="Rupprecht">Charles E. Rupprecht</name><name sortKey="Street, Craig" sort="Street, Craig" uniqKey="Street C" first="Craig" last="Street">Craig Street</name><name sortKey="Tashmukhamedova, Alla" sort="Tashmukhamedova, Alla" uniqKey="Tashmukhamedova A" first="Alla" last="Tashmukhamedova">Alla Tashmukhamedova</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Quan, Phenix Lan" sort="Quan, Phenix Lan" uniqKey="Quan P" first="Phenix-Lan" last="Quan">Phenix-Lan Quan</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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